Nutrigenomics of vitamin C absorption and transport

作者：Eck Peter^*

来源：Current Opinion in Food Science, 2018, 20: 100-104.

DOI：10.1016/j.cofs.2018.05.001

Associations of individual single nucleotide polymorphisms (SNPs) in the human genes encoding for the ascorbic acid transporters SLC23A1 and SLC23A2 were reviewed. SNPs in both genes modify circulating ascorbic concentrations, the risks for various cancers, cardiovascular outcomes, inflammatory bowel disease, and ocular diseases. Disease associations are inconsistent and impact sizes are generally moderate. The impact sizes of SNPs on circulating ascorbic acid concentrations are moderate and reported changes did not alter the populations' vitamin C status. Associations for the SLC23A1 and SLC23A2 genes are currently poorly validated, limiting their utility as diagnostic or predictive biomarkers.

• 出版日期2018-4