Abnormal orbitofrontal development due to prematurity

作者：Gimenez M; Junque C^*; Vendrell P; Narberhaus A; Bargallo N; Botet F; Mercader J M

来源：Neurology, 2006, 67(10): 1818-1822.

DOI：10.1212/01.wnl.0000244485.51898.93

Objective: To investigate the effects of prematurity on sulcal formation. Methods: We evaluated the depth and volume of the primary olfactory sulcus ( developed at 16 weeks' gestation) and the secondary orbital sulci ( which start to develop at 28 weeks' gestation) in a sample of 22 adolescents with history of very-preterm birth (VPTB). We compared this preterm sample with a sample of subjects born at term and matched by age, gender, and sociocultural status. The Anatomist/BrainVISA 3.0.1 package was used to identify and quantify the sulci. In addition, voxel-based morphometry (VBM) was used to analyze possible reductions of gray and white matter in the orbitofrontal area. Results: Compared with controls, we found a significant reduction in the secondary sulci depth but not in the primary sulcus in the VPTB. VBM analysis showed reduced gray-matter volume in VPTB in the orbital region. Conclusions: Premature birth affects cerebral gyrification, and this impairment is not reversible during childhood. Identification of the specific factors involved in abnormal brain maturation may lead to effective interventions.

• 出版日期2006-11-28