科研之友
微信
新浪微博
Facebook
分享链接
摘要
This is the first report of a successful asymmetric aldol reaction of acetone and 4-nitrobenzaldehyde catalyzed by only 0.01 mol% of proline tetrazole (5-pyrrolidin-2-yltetrazole). Amazingly, 3 mol% of water as an additive has significantly improved the efficiency of the aldol reaction in terms of yield and enantioselectivity, up to a 0.1mol-scale production (up to 99% isolated yield, 84% ee).
- 出版日期2017-1
