Age-related pro-inflammatory and pro-angiogenic changes in human aqueous humor

作者：Zheng, Yan; Rao, Yu-Qing; Li, Jia-Kai; Huang, Yue; Zhao, Peiquan^*; Li, Jing

来源：International Journal of Ophthalmology, 2018, 11(2): 196-200.

DOI：10.18240/ijo.2018.02.03

• aqueous humor
• cytokines
• aging
• parainflammation
• macrophage
• vascular endothelial growth factor

AIM: To reveal age-related aqueous cytokine changes in human aqueous humor. @@@ METHODS: Aqueous humor was collected from 12 young children (3-6.5 years old) and 71 healthy adults (22106 years old) with cataract but without other systemic or ocular disorders. Levels of 22 cytokines, chemokines and vascular endothelial growth factor (VEGF) were measured and analyzed. @@@ RESULTS: The following proteins showed significant increase from childhood to adult: interferon-gamma (IFN-gamma), interleukin (IL)-13, IL-6, IL-12(p70), IL-10, CCL2, CCL3, CCL4, CXCL8, CXCL9, CXCL10, IFN-alpha 2 and VEGF (all P<0.05). IFN-gamma, IL-13, IL-12(p70), IL-10, CCL3, CXCL9 and VEGF also showed moderate strength age-related increase in the adult group (r>0.5). The strength of correlation between aging and CCL4 were fair (r=0.398). The concentrations of IL-2, IL-4, IL-5, IL-1 beta and TNF-alpha were low in both groups. @@@ CONCLUSION: From childhood to adult, the immunological milieu of the anterior chamber become more pro-inflammatory and pro-angiogenic. Such changes may represent the parainflammation state of the human eye.

• 出版日期2018-2-18
• 单位上海交通大学