Uses of 2-amino-3-cyano-5,5-dimethyl-7-oxocyclohexano[b]thiophene in heterocyclic synthesis

作者：Wardakhan Wagnat W^*; Yousef Adel M; Hamed Faten I

来源：Phosphorus, Sulfur, and Silicon and the Related Elements, 2007, 182(7): 1507-1523.

DOI：10.1080/10426500701247052

• dimedone
• cyclohexeno[b]thiophene
• pyrazole
• pyridazine

The reaction of 2-diazo-3-cyano-5,5-dimethyl-7-oxocycloheneno-[b]thiophene (4) with the active methylene reagents 2, 5, 12a, or 12b gave the hydrazo derivatives 6a,b and 13ab, respectively. The reactivity of the latter products towards different reagents was studied to give pyrazole, pyridazine, 1,2,4-triazine, and thieno[3,4-d]pyridazine derivatives. The antimicrobial and antifungal activities of the newly synthesized products were measured against the three bacterial isolates (Bacillus Subtillis, Escherichia Coli, and Pseudomonas Aeruginosa) and the three fungal isolates (Candida Albicans, C Glabrata, and A. Fumigatus).

• 出版日期2007-7