Analysis of Short-Term Change in Subfoveal Choroidal Thickness in Eyes With Age-Related Macular Degeneration Using Optical Coherence Tomography

作者：Fein Jordana G^*; Branchini Lauren A; Manjunath Varsha; Regatieri Caio V; Fujimoto James G; Duker Jay S

来源：Ophthalmic Surgery, Lasers and Imaging, 2014, 45(1): 32-37.

DOI：10.3928/23258160-20131220-04

BACKGROUND AND OBJECTIVE: To measure the sub-foveal choroidal thickness in patients with age-related macular degeneration (AMD) over 6 months.
PATIENTS AND METHODS: A retrospective, observational study of patients with AMD followed up for 6 months at the New England Eye Center. Baseline and 6-month follow-up subfoveal choroidal thickness was measured using spectral-domain OCT and compared.
RESULTS: For the entire cohort, there was statistically significant thinning of the subfoveal choroidal thickness at 6 months compared to baseline that was driven by the cohort of patients with neovascular AMD (181.2 +/- 75 mu m to 173.4 +/- 63 mu m; P=.049).
CONCLUSION: There was a statistically significant decrease in subfoveal choroidal thickness observed in this cohort of patients with AMD over 6 months, but it was driven by the subgroup of patients with neovascular age-related macular degeneration.

• 出版日期2014-2
• 单位MIT