Main Bile Duct Stricture Occurring After Transcatheter Arterial Chemoembolization for Hepatocellular Carcinoma

作者：Miyayama Shiro^*; Yamashiro Masashi; Okuda Miho; Yoshie Yuichi; Nakashima Yoshiko; Ikeno Hiroshi; Orito Nobuaki; Notsumata Kazuo; Watanabe Hiroyuki; Toya Daisyu; Tanaka Nobuyoshi; Matsui Osamu

来源：CardioVascular and Interventional Radiology, 2010, 33(6): 1168-1179.

DOI：10.1007/s00270-009-9781-6

• Hepatocellular carcinoma
• Transcatheter arterial chemoembolization
• Bile duct stricture
• Jaundice
• Biloma
• Metallic stent placement

The purpose of this study was to evaluate the clinical course of main bile duct stricture at the hepatic hilum after transcatheter arterial chemoembolization (TACE) for hepatocellular carcinoma (HCC) Among 446 consecutive patients with HCC treated by TACE main bile duct stricture developed in 18 (4 0%) All imaging and laboratory data treatment course, and outcomes were retrospectively analyzed All patients had 1 to 2 tumors measuring 10 to 100 mm in diameter (mean +/- SD 24 5 +/- 5 4 mm) near the hepatic hilum fed by the caudate arterial branch (A1) and/or medial segmental artery (A4) of the liver During the TACE procedure that caused bile duct injury A1 was embolized in 8 A4 was embolized in 5, and both were embolized in 5 patients Nine patients (50 0%) had a history of TACE in either A1 or A4 Iodized oil accumulation in the bile duct wall was seen in all patients on computed tomography obtained I week later Bile duct dilatation caused by main bile duct structure developed in both lobes (n = 9) in the right lobe (n = 3), in the left lobe (n = 4), in segment (S) 2 (n = 1), and in S3 (n = 1) Serum levels of alkaline phosphatase gamma-glutamyltranspeptidase increased in 13 patients Biloma requiring drainage developed in 2 patients, jaundice developed in 4 patients, and metallic stents were placed in 3 patients Complications after additional TACE sessions, including biloma (n = 3) and/or jaundice (n = 5), occurred in 7 patients and were treated by additional intervention including metallic stent placement in 2 patients After initial TACE of A1 and/or A4 8 patients (44 4%) including 5 with uncontrollable jaundice or cholangitis, died at 37 9 +/- 34 9 months after TACE, and 10 (55 6%) have survived for 38 4 +/- 37 9 months Selective TACE of A1 and/or A4 carries a risk of main bile duct stricture at the hepatic hilum Biloma and jaundice are serious complications associated with bile duct strictures.

• 出版日期2010-12