Mitomycin C Does Not Inhibit Exacerbation of Granular Corneal Dystrophy Type II Induced by Refractive Surface Ablation

作者：Ha Byoung Jin; Kim Tae im; Choi Seung il; Stulting R Doyle; Lee Dong Ho; Cho Hyun Soo; Kim Eung Kweon^*

来源：Cornea, 2010, 29(5): 490-496.

DOI：10.1097/ICO.0b013e3181c3258a

• granular corneal dystrophy type II
• avellino corneal dystrophy
• mitomycin C
• keratoepithelin
• BIGH3
• surface ablation
• LASEK
• PRK
• PTK
• TGF-beta
• pentacam

Purpose: To evaluate the effect of mitomycin C (MMC) on the exacerbation of corneal opacity that occurs in patients with granular corneal dystrophy type II (GCD II) after refractive corneal surface ablation.
Methods: Ten eyes of patients with GCD II who underwent refractive corneal surface ablation with MMC were compared with 10 eyes that were not treated with MMC. Best spectacle-corrected visual acuity, the degree of corneal opacity, and contrast sensitivity were evaluated at least 3 years after surgery. Corneal opacities were quantified using Pentacam densitometry maps.
Results: No measured between-group value showed a statistically significant difference.
Conclusion: Simultaneous application of MMC does not prevent exacerbation of GCD II after refractive corneal surface ablation.

• 出版日期2010-5