Prolonged and symptomatic bradycardia following a single dose of fingolimod

作者：Faber Hans^*; Fischer Hans Joerg; Weber Frank

来源：Multiple Sclerosis, 2013, 19(1): 126-128.

DOI：10.1177/1352458512447596

• bradycardia
• disease modifying therapies
• fingolimod
• multiple sclerosis

Fingolimod-related bradycardia is usually asymptomatic, reaches its nadir within 6 hours post-dose and recovers spontaneously. Here we report the case of a 30-year-old MS patient with vagotonia who developed symptomatic bradycardia with 33 beats per minute at nadir 39 hours after a single dose of fingolimod. Bradycardia was responsive to atropine, but returned within 2 hours. Overall, it took a week until the patient recovered. Extended monitoring is advised in patients with symptomatic bradycardia.

• 出版日期2013-1