Association of IL-12p40+1188 A/C polymorphism with nasopharyngeal cancer risk and tumor extension

作者：Ben Chaaben A; Busson M; Douik H; Boukouaci W; Mamoghli T; Chaouch L; Harzallah L; Dorra S; Fortier C; Ghanem A; Charron D; Krishnamoorthy R; Guemira F; Tamouza R^*

来源：Tissue Antigens, 2011, 78(2): 148-151.

DOI：10.1111/j.1399-0039.2011.01702.x

• IL-12p40 polymorphism
• nasopharyngeal carcinoma
• Tunisia

The interleukin 12 (IL-12) cytokine, encoded by polymorphic genes, plays a central role in the T helper 1 cell-mediated immunity against tumors. We investigated whether the 3' untranslated region +1188 A/C polymorphism (rs 3212227) influences the nasopharyngeal carcinoma (NPC) risk in Tunisian patients. DNA analysis of 247 patients and 284 healthy individuals showed a higher frequency of the 1188 C allele and the CC genotype in patients than in controls (P = 0.00001 and P = 0.00005) suggesting that the C variant allele is associated with the susceptibility to NPC. Additional testing showed that the homozygous CC genotype is also associated with advanced stage of the tumor extension at presentation (P = 0.022). Our data suggest that the impaired production of IL-12 behaves as a risk factor for NPC occurrence and progression.

• 出版日期2011-8