Application of an in vitro digestion model for Po-210 bioaccessibility assessment in seafood

作者：Roselli Carla; Desideri Donatella; Feduzi Laura; Ugolini Lucia; Meli Maria Assunta^*

来源：Journal of Radiological Protection, 2017, 37(4): 907-917.

DOI：10.1088/1361-6498/aa869b

• polonium bioaccessibility
• gastric and gastrointestinal digestion
• seafood

This study aims to investigate the bioaccessibility of Po-210 in seafood and the impact of food preparation on this radionuclide. Polonium bioaccessibility is the fraction of (21)0Po mobilised from food matrices into digestive extractants when applying an in vitro digestion model. The degree of bioaccessibility of Po-210 in food has important implications for estimating ingestion doses from this radionuclide. The simulation of gastrointestinal digestion was divided into three stages through the use of synthetic saliva, gastric and bile-pancreas solutions. Following pre-treatment with a saliva solution, raw and cooked seafood samples underwent one of the following treatments: (a) simulated gastric digestion only or (b) simulated complete gastrointestinal digestion (gastric digestion followed by bile-pancreas digestion). No significant difference (P > 0.05) in Po-210 mobility was found between samples that underwent gastric digestion compared to those that only underwent gastro-intestinal digestion. However, a significant difference (P < 0.05) in Po-210 bioaccessibility was found between raw and cooked seafood undergoing both gastric and gastro-intestinal digestion.

• 出版日期2017-12