A novel arc geometry setting for pelvic radiotherapy with extensive nodal involvement

作者：Rossi Maija^*; Boman Eeva; Skytta Tanja; Kapanen Mika

来源：Journal of Applied Clinical Medical Physics, 2016, 17(4): 73-85.

DOI：10.1120/jacmp.v17i4.6028

• anorectal carcinoma
• vulvar cancer
• treatment planning
• arc therapy
• wide fields

The aim of this study was to find optimal planning approach for large planning targets with complicated geometry requiring wide field openings. The study presents a novel approach for arc geometry design for pelvic targets with extensive nodal involvement. A total of 15 patients with anorectal carcinoma or vulvar cancer were selected retrospectively. For each patient, one seven-field IMRT plan and three VMAT plans were calculated: one with two 360 degrees arcs with no limitations for the field size (VMATw); one with two asymmetrically field-size-restricted 360 degrees arcs (VMATr); and the proposed novel approach which consisted of one 360 degrees arc with the field size restricted to the central PTV, and another arc divided into two 180 degrees arcs, restricting the field sizes with the focus on the lymph nodes. The techniques were compared in terms of PTV coverage (V-PTV(95%)), dose maximum (D(max)), dose conformity index (CI), homogeneity index (HI), and organs at risk doses. The proposed novel approach with one full and two half arcs tended to have better PTV coverage (V-PTV(95%) = 97% +/- 2%, compared to 95% +/- 3%, 95% +/- 3%, and 97% +/- 2% in VMATw, VMATr, and 7f-IMRT, respectively) and lower maxima (D(max) = 107% +/- 1%, compared to 110% +/- 3%, 110% +/- 4%, and 110% +/- 4% in VMATw, VMATr, and 7f-IMRT, respectively); and lower or equal organs at risk doses. The superiority of the proposed technique (CI = 1.16 +/- 0.05, HI = 9 +/- 2) was more pronounced compared with the VMATw plans (CI = 1.41 +/- 0.10, paired t-test p < 0.001; HI = 12 +/- 2, p < 0.001), but the proposed technique was slightly better also in comparison with the VMATr plans (CI = 1.21 +/- 0.07, p < 0.001; HI = 11 +/- 4, p = 0.015) and 7f-IMRT plans (CI = 1.18 +/- 0.03, p = 0.016; HI = 10 +/- 2, p = 0.215). Radiotherapy treatment planning for large and complicated treatment volumes benefits not only from restricting the field size but also from careful field design that considers PTV geometry. This optimizes multileaf collimator movements, leading to better dose conformity and homogeneity.

• 出版日期2016