Discovery of a Phosphoinositide 3-Kinase (PI3K) beta/delta Inhibitor for the Treatment of Phosphatase and Tensin Homolog (PTEN) Deficient Tumors: Building PI3K beta Potency in a PI3K delta-Selective Template by Targeting Nonconserved Asp856

Perreault Stephane; Chandrasekhar Jayaraman; Cui Zhi Hua; Evarts Jerry; Hao Jia; Kaplan Joshua A; Kashishian Adam; Keegan Kathleen S; Kenney Thomas; Koditek David; Lad Latesh; Lepist Eve Irene; McGrath Mary E; Patel Leena; Phillips Bart; Therrien Joseph; Treiberg Jennifer; Yahiaoui Anella; Phillips Gary

doi:10.1021/acs.jmedchem.6b01821

免费注册

赞收藏引用

科研之友

微信

新浪微博

Facebook

分享链接

Discovery of a Phosphoinositide 3-Kinase (PI3K) beta/delta Inhibitor for the Treatment of Phosphatase and Tensin Homolog (PTEN) Deficient Tumors: Building PI3K beta Potency in a PI3K delta-Selective Template by Targeting Nonconserved Asp856

作者：Perreault Stephane; Chandrasekhar Jayaraman; Cui Zhi Hua; Evarts Jerry; Hao Jia; Kaplan Joshua A; Kashishian Adam; Keegan Kathleen S; Kenney Thomas; Koditek David; Lad Latesh; Lepist Eve Irene; McGrath Mary E; Patel Leena; Phillips Bart; Therrien Joseph; Treiberg Jennifer; Yahiaoui Anella; Phillips Gary

来源：Journal of Medicinal Chemistry, 2017, 60(4): 1555-1567.

DOI：10.1021/acs.jmedchem.6b01821