Detecting Field Cancerization Using a Hyperspectral Imaging System

作者：Neittaanmaki Perttu Noora^*; Gronroos Mari; Tani Taneli; Polonen Ilkka; Ranki Annamari; Saksela Olli; Snellman Erna

来源：Lasers in Surgery and Medicine, 2013, 45(7): 410-417.

DOI：10.1002/lsm.22160

• actinic keratosis
• field cancerization
• hyperspectral imaging

BackgroundField cancerization denotes subclinical abnormalities in a tissue chronically exposed to UV radiation. These abnormalities can be found surrounding the clinically visible actinic keratoses. %26lt;br%26gt;ObjectivesThe aim of this study was to test the feasibility of a hyperspectral imaging system in the detection of multiple clinical and subclinical AKs for early treatment of the affected areas. %26lt;br%26gt;Materials and MethodsAltogether 52 clinical AKs in 12 patients were included in this study. In six patients digital photos were taken of the naive AKs, and again after methylaminolevulinate(MAL)-fluorescence diagnosis which was used to teach HIS to find subclinical lesions. After 2-3 days when the MAL had vanished, the hyperspectral images were taken. Biopsies were taken from clinical AKs, healthy-looking skin and several suspected subclinical AKs. In the other six patients digital and hyperspectral images were taken of the naive AKs followed by one biopsy per patient. %26lt;br%26gt;ResultsHIS detected all clinically visible 52 AKs and numerous subclinical lesions. The histopathology of the 33 biopsied lesions were concordant with the HIS results showing either AK (n=28) or photodamage (n=5). Of the 28 histopathologically confirmed AKs, 16 were subclinical. A specific diffuse reflectance spectrum of an AK and healthy skin was defined. %26lt;br%26gt;ConclusionThe hyperspectral imaging system offers a new, non-invasive method for early detection of field cancerization. Lasers Surg. Med. 45:410-417, 2013.

• 出版日期2013-9