科研之友
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摘要
Noble metal nanoparticles (e.g., Au, Ag, and Cu) hold significant potential in photothermal therapy due to their excellent photothermal conversion efficiency. In this study, Au-Ag nanoframes were synthesized through a simple galvanic replacement reaction between Ag nanoboxes and chloroauric acid in solution phase. The plasmon resonance absorption wavelength of the Au-Ag nanoframes was easily adjusted by changing the size of the starting Ag nanoboxes. Anti-CK 19, a polyclonal antibody, was linked to the surface of Au-Ag nanoframes to target cancer cells for photothermal therapy. Experiment results verified that the antibody guided Au-Ag nanoframes exhibited low biotoxicity, high specificity and therapeutic efficiency.
