NEW INDOLE ALKALOIDS FROM ALSTONIA MACROPHYLLA

作者：Deguchi Jun^*; Shoji Tomokazu; Hirasawa Yusuke; Rahman Abdul; Shirota Osamu; Morita Hiroshi

来源：Heterocycles, 2012, 86(2): 1603-1610.

DOI：10.3987/COM-12-S(N)112

• Indole Alkaloid
• Kopsia singapurensis
• Aspidofractinine
• Aspidospermatan
• Akuamiline

Alkaloidal investigations of Alstonia macrophylla led to the isolation of a new 3-alkylpyridinium-indole-2-carboxylate scaffold alkaloid, N(1)-demethyl-7-methoxyikirydinium A (1) and a yohimbane-type alkaloid, 10-methoxydihydrosempervirine (2), and two strychane-type alkaloids, 17-carboxylcompactivervine N-oxide (3) and 17-carboxylalstovine N-oxide (4). Their structures were elucidated by NMR spectral analysis using 2D techniques and CD spectra.

• 出版日期2012-12-31