Diastereoselective Addition of Organomagnesium and Organolithium Reagents to Chiral Trifluoromethyl N-tert-Butanesulfinyl Hemiaminals

作者：Grellepois Fabienne^*; Ben Jamaa Abdelkhalek; Gassama Abdoulaye

来源：European Journal of Organic Chemistry, 2013, 2013(29): 6694-6701.

DOI：10.1002/ejoc.201300890

• Asymmetric synthesis
• Allylation
• Reduction
• Alkylation
• Fluorine

The asymmetric synthesis of trifluoromethylated tertiary and secondary carbinamines (,-dibranched and -branched amines) was achieved by reaction of alkyl, aryl and allyl organomagnesium or organolithium reagents to trifluoromethyl N-tert-butanesulfinyl hemiaminals, bench-stable analogs of the corresponding ketoimines.

• 出版日期2013-10