Acute Oxaliplatin-induced Hemolytic Anemia, Thrombocytopenia, and Renal Failure: Case Report and a Literature Review

作者：Phull Pooja; Quillen Karen; Hartshorn Kevan L^*

来源：Clinical Colorectal Cancer, 2017, 16(2): E105-E107.

DOI：10.1016/j.clcc.2016.11.005

• Colorectal cancer
• Evan syndrome
• Hemolysis
• Hypersensitivity
• Immune thrombocytopenia

Oxaliplatin is commonly used for treatment of colorectal, gastric, and pancreatic cancers.
Acute hypersensitivity reactions, thrombotic thrombocytopenic purpura, and Evan syndrome (autoimmune hemolysis and thrombocytopenia) have been described after repeated administration of oxaliplatin.
We describe a case in which acute autoimmune hemolysis and renal failure and thrombocytopenia occurred after re-treatment with oxaliplatin.
This case is distinct from previous reports in the specific constellation of findings and the detailed analysis of red cell autoantibodies involved.
Treating providers should be aware of the spectrum of immune reactions that can occur in patients previously sensitized to oxaliplatin.

• 出版日期2017-6