Phenotypic Characteristics in GBA-Associated Parkinson's Disease: A Study in a Greek Population

作者：Simitsi Athina; Koros Christos; Moraitou Marina; Papagiannakis Nikos; Antonellou Roubina; Bozi Maria; Angelopoulou Efthalia; Stamelou Maria; Michelakakis Helen; Stefanis Leonidas^*

来源：Journal of Parkinson's Disease, 2018, 8(1): 101-105.

DOI：10.3233/JPD-171221

• Cognitive decline
• environmental exposure
• glucocerebrosidase
• Parkinson's disease

We compared phenotypic characteristics in 35 Greek patients with Parkinson's disease (PD), carriers of GBA1 mutations (GBA-PD), with 35 Genetically Unidentified PD patients (GU-PD). We found a previously reported higher prevalence of cognitive impairment and a little appreciated more frequent bilateral onset of the disease in GBA-PD vs GU-PD. As far as the exposure to environmental factors, linked to PD, is concerned, our study hints to the possibility that pesticide exposure may be more common in GBA-PD patients, and possibly act synergistically with the mutation carrier status to trigger the disease.

• 出版日期2018