A quartz crystal microbalance method to study the terminal functionalization of glycosaminoglycans

作者:Thakar Dhruv; Migliorini Elisa; Coche Guerente Liliane; Sadir Rabia; Lortat Jacob Hugues; Boturyn Didier; Renaudet Olivier; Labbe Pierre; Richter Ralf P*
来源:Chemical Communications, 2014, 50(96): 15148-15151.
DOI:10.1039/c4cc06905f

摘要

We demonstrate the quartz crystal microbalance as a novel method to quantify the reaction yields and stability of the terminal conjugation of chemically complex molecules. Oxime ligation is identified as a facile, broadly applicable method for the reducing-end conjugation of glycosaminoglycans that overcomes the limited stability and yield of popular hydrazone ligation.

  • 出版日期2014
  • 单位中国地震局