A novel thiochromone-type photolabile protecting group for carbonyl compounds

作者：Sugiura Ryo; Kozaki Rikio; Kitani Satoru; Gosho Yoshinori; Tanimoto Hiroki; Nishiyama Yasuhiro; Morimoto Tsumoru; Kakiuchi Kiyomi^*

来源：Tetrahedron, 2013, 69(19): 3984-3990.

DOI：10.1016/j.tet.2013.03.022

• Photolabile protecting group
• Thiochromone
• 1,2-Diol
• Carbonyl compound
• Photodeprotection

A novel photolabile protecting group, thiochromone S,S-dioxide, possessing the 1,2-diol group for protection of ketones and aldehydes is described. Photodeprotection of the successfully protected carbonyl derivatives proceeded smoothly under photoirradiation filtered through Pyrex glass (%26gt;280 nm) using an ultrahigh-pressure mercury lamp to recover the corresponding carbonyl compounds and the starting protecting group.

• 出版日期2013-5-13