Arrestin makes T cells stop and become active

作者：Gurevich Vsevolod V^*; Gurevich Eugenia V

来源：The EMBO Journal, 2014, 33(6): 531-533.

DOI：10.1002/embj.201387724

T-cell activation requires signaling by T-cell receptors (TCRs) that bind antigen on the antigen-presenting cells (APCs) at the immunological synapse (IS). Sustained signaling requires continuous supply of new TCRs to the IS. In this issue of The EMBO Journal, Fernandez-Arenas etal () describe a novel role of -arrestin-1 at the IS periphery: endocytosis of TCRs and chemokine CXCR4 receptors. Internalized TCRs are then delivered to the IS, where they engage antigen and support prolonged signaling, whereas CXCR4 internalization stops T-cell migration.

• 出版日期2014-3-18