科研之友
微信
新浪微博
Facebook
分享链接
摘要
The enantioselective formation of alpha-aryloxy-beta-keto esters is described for the first time. Lewis acid catalyzed enantioselective chlorination of beta-keto esters and subsequent S(N)2 reactions with phenols yielded alpha-aryloxy-beta-keto esters with up to 96% ee. Favorskii rearrangement of alpha-chloro-beta-keto esters was also found to give 1,2-diesters with slightly reduced enantiopurity.
- 出版日期2015-9-28
