Developmental expression of glucokinase in rat hypothalamus

作者：Sutherland VL; McReynolds M; Tompkins LS; Brooks HL; Lynch RM^*

来源：Developmental Brain Research, 2005, 154(2): 255-258.

DOI：10.1016/j.devbrainres.2004.11.001

• endocrine and autonomic regulation
• neuroendocrine regulation
• other
• glucose sensing
• glucokinase
• RT-PCR
• development

Neurons in the hypothalamus sense changes in glucose concentration. Glucokinase (GK), a key enzyme for pancreatic (beta)-cell glucose sensing, was found in both the embryonic and adult hypothalamus. GK activity accounted for approximately 20% of total hexokinase (HK) activity in both embryonic and adult hypothalamus with no activity measured in cor

• 出版日期2005-2-8