Acute Lymphoblastic Leukemia; Prognostic Factors' Perspective

作者：Tekgunduz Emre^*; Demir Muzaffer; Akpinar Seval

来源：Uluslararasi Hematoloji-Onkoloji Dergisi, 2010, 20(1): 57-66.

• Acute lymphoblastic leukemia
• Prognosis
• Risk factors

Acute lymphoblastic leukemia represents a biologically and clinically heterogeneous group of diseases with different outcomes among patients subgroups. Identification of prognostic factors is critical in selecting therapy for subgroups of patients to achieve a high cure rate with minimal toxicity. Another important goal of risk stratification is to define patients with a very high risk of relaps, who may benefit from up-front allogeneic hematopoietic stem cell transplantation following first complete remission. Clinical parameters, immunophenotype, cytogenetics, treatment response, minimal residual disease are among currently used factors in risk stratification of acute lymphoblastic leukemia patients. But there are emerging new parameters like global gene expression profiling, host pharmacodynamics-pharmacogenetics and treatment protocols which may have an impact on risk-adapted treatment in the near future. In the present review we will discuss a variety of prognostic factors and their impact on clinical outcome of children and adults with acute lymphoblastic leukemia.

• 出版日期2010-3