Mining Plants for Bacterial Quorum Sensing Modulators

作者:David Shimrit; Mandabi Aviad; Uzi Shaked; Aharoni Asaph; Meijler Michael M.*
来源:ACS Chemical Biology, 2018, 13(1): 247-252.
DOI:10.1021/acschembio.7b00859

摘要

The bacterial plant pathogen Agrobacterium tumefaciens uses quorum sensing (QS) in order to regulate the transfer of DNA into the host plant genome, and this results in the induction of crown gall tumors. The deleterious results of these infections are widespread and affect many species of fruit and crops. In order to further our understanding, of this process and to provide potential solutions, we evaluated a library of 3800 natural products from plant sources and identified potent compounds that are able to strongly modulate plant-bacterial interactions.

  • 出版日期2018-1