A Novel Preparation Method for 5-Aminosalicylic Acid Loaded Eudragit S100 Nanoparticles

作者：Hu, Daode^*; Liu, Liang; Chen, Wenjuan; Li, Sining; Zhao, Yaping

来源：International Journal of Molecular Sciences, 2012, 13(5): 6454-6468.

DOI：10.3390/ijms13056454

• supercritical antisolvent
• solution enhanced dispersion by supercritical fluids
• Eudragit S100
• 5-ASA
• nanoparticles
• colon-specific

In this study, solution enhanced dispersion by supercritical fluids (SEDS) technique was applied for the preparation of 5-aminosalicylic acid (5-ASA) loaded Eudragit S100 (EU S100) nanoparticles. The effects of various process variables including pressure, temperature, 5-ASA concentration and solution flow rate on morphology, particle size, 5-ASA loading and entrapment efficiency of nanoparticles were investigated. Under the appropriate conditions, drug-loaded nanoparticles exhibited a spherical shape and small particle size with narrow particle size distribution. In addition, the nanoparticles prepared were characterized by X-ray diffraction, Differential scanning calorimetry and Fourier transform infrared spectroscopy analyses. The results showed that 5-ASA was imbedded into EU S100 in an amorphous state after SEDS processing and the SEDS process did not induce degradation of 5-ASA.

• 出版日期2012-5
• 单位上海交通大学