Development of low methoxy amidated pectin-based mucoadhesive patches for buccal delivery of triclosan: Effect of cyclodextrin complexation

作者：Jug Mario^*; Kosalec Ivan; Maestrelli Francesca; Mura Paola

来源：Carbohydrate Polymers, 2012, 90(4): 1794-1803.

DOI：10.1016/j.carbpol.2012.07.074

• Triclosan
• beta-Cyclodextrin
• Water soluble polymeric beta-cyclodextrin
• Low methoxy amidated pectin
• Carbopol
• Buccal delivery

A novel mucoadhesive buccal patch formulation of triclosan (TR), a broad spectrum antibacterial agent, was developed using low methoxy amidated pectin (AMP). The integrity of AMP matrix was improved by addition of 20% (w/w) Carbopol (CAR). The efficiency of beta-cyclodextrin-epichlorohydrin polymer (EPI beta CD) and anionic carboxymethylated beta-cyclodextrin-epichlorohydrin polymer (CMEPI beta CD) in optimization of TR solubility and release from such a matrix was investigated and confronted to that of parent beta-cyclodextrin (beta CD). Loading of TR/beta CD co-ground complex into AMP/CAR matrix resulted in a biphasic release profile which was sensitive upon the hydration degree of the matrix, due to lower solubilizing efficiency of beta CD, while the drug release from patches loaded with TR/EPI beta CD complex was significantly faster with a constant release rate. Microbiological studies evidenced faster onset and more pronounced antibacterial action of TR/EPI beta CD loaded patches, clearly demonstrating their good therapeutic potential in eradication of Streptococcus mutans. a cariogenic bacteria, from the oral cavity.

• 出版日期2012-11-6