A large, nationwide, longitudinal study of central nervous system diseases among Korean workers exposed to manganese

作者：Yoon Jin Ha; Ahn Yeon Soon^*

来源：Parkinsonism & Related Disorders, 2015, 21(3): 194-198.

DOI：10.1016/j.parkreldis.2014.11.021

• Manganese
• Central nervous system diseases
• Parkinsonism
• Degenerative nervous system diseases
• Occupational epidemiology

Introduction: In occupational epidemiologic studies, the low incidence and chronic process of central nervous system (CNS) diseases has complicated the determination of the relationship between increased morbidity and manganese (Mn) exposure. Therefore, through this large cohort study, we evaluated CNS disease morbidity among Korean workers exposed to Mn
Methods: Data were collected from Mn-associated specialized medical check-up 2000 and 2004 in Korea. The number of workers admitted to hospital because of clinically diagnosed CNS disease was analyzed in male workers exposed to Mn (n = 104,544). As a control reference population, 2% of Korean men were randomly selected and their hospital admission data were analyzed. For Mn-exposed workers, Standardized admission ratios (SARs) for CNS disease, as determined by ICD-10 classifications, were estimated in reference to the control population
Results: During follow up, 64 workers admitted because of CNS diseases. Chronic exposure to Mn (>10 years) was significantly associated with the SAR (95% CI) of extrapyramidal and movement disorders (SAR: 2.03, 95% CI: 1.05-3.55), in particular, other extrapyramidal and movement disorders (SAR: 4.81, 95% Cl: 1.29-12.32). Also borderline association (SAR = 4.88, 90% Cl: 1.05-7.04) was noted for secondary Parkinsonism among workers with chronic Mn exposure. SARs (95% Cl) for other degenerative nervous system diseases were significantly higher in Mn-exposed workers compared with the control population (SAR: 3.60, 95% Cl: 1.16-8.40)
Conclusion: In conclusion, Mn-exposed workers exhibited significantly elevated SARs for degenerative ne

• 出版日期2015-3