Stereoselectivity and conformational control in the synthesis of ajmaline and epi-ajmaline alkaloids

作者：Bailey Patrick D^*; Beard Mark A; Cresswell Mark; Dang Hoa P T; Pathak Ravindra B; Phillips Theresa R; Price Richard A

来源：Tetrahedron Letters, 2013, 54(13): 1726-1729.

DOI：10.1016/j.tetlet.2013.01.074

• Stereoselective synthesis
• Indole alkaloids
• Ajmaline

Careful choice of the N-protecting group provides crucial conformational control, allowing ring-closure to the indole 3-position in the late stages of the synthesis of ajmaline alkaloids; the choice of protecting group and reducing agent can also provide access to either the natural or epi configuration at the indole 2-position.

• 出版日期2013-3-27