A ruthenium(II) complex capable of inducing and stabilizing bcl-2 G-quadruplex formation as a potential cancer inhibitor

作者：Zhang, Jingnan; Yu, Qianqian; Li, Qian; Yang, Licong; Chen, Lanmei; Zhou, Yanhui^*; Liu, Jie

来源：Journal of Inorganic Biochemistry, 2014, 134: 1-11.

DOI：10.1016/j.jinorgbio.2013.12.005

• Ruthenium
• Bcl-2
• G-quadruplexes
• DNA structures
• Anticancer

Two ruthenium(II) complexes (Ru-complexes) were synthesized and characterized in this study. The selectivity and ability of the complexes to interact with bcl-2 DNA were investigated here. It turned out that [Ru(ip)(3)]ClO4)2 center dot 2H(2)O (complex 1, ip = 1H-iminazole [4,5-f][1,10] phenanthroline) could induce and stabilize the formations of G-quadruplexes more effectively than [Ru(pip)(3)](ClO4)(2)center dot 2H(2)O (complex 2, pip = 2-phenylimidazo-[4,5-f][1,10]phenanthroline) did. Considering the important role of the Ru-complex ligand in inducing and stabilizing the formations of G-quadruplex in our previous studies, we speculate that the overlarge ligand of complex 2 may block its binding affinity for G-quadruplexes. Complex 1 also induced cell apoptosis in in vitro assays. In general, this study provided potentially important informat

• 出版日期2014-5
• 单位暨南大学; 广东医科大学