Nitroreductase-triggered activation of a novel caged fluorescent probe obtained from methylene blue

作者:Bae Jungeun; McNamara Louis E; Nael M**** A; Mahdi Fakhri; Doerksen Robert J; Bidwell Gene L III; Hammer Nathan I; Jo Seongbong*
来源:Chemical communications, 2015, 51(64): 12787-12790.
DOI:10.1039/c5cc03824c

摘要

A near-infrared fluorescent probe based on methylene blue (p-NBMB) was developed for the detection of nitroreductase. Conjugating methylene blue with a p-nitrobenzyl moiety enables it to be activated by nitroreductase-catalyzed 1,6-elimination, resulting in the release of an active methylene blue fluorophore.

  • 出版日期2015