Detecting Improvements in Dyspnea in COPD Using a Three-Minute Constant Rate Shuttle Walking Protocol

作者：Sava Francesco; Perrault Helene; Brouillard Cynthia; Darauay Carmen; Hamilton Alan; Bourbeau Jean; Maltais Francois^*

来源：Journal of Chronic Obstructive Pulmonary Disease, 2012, 9(4): 395-400.

DOI：10.3109/15412555.2012.674164

• COPD
• exercise
• shuttle walking test
• bronchodilation
• dyspnea

Rationale: We examined the responsiveness of a 3-minute constant rate shuttle walking protocol to detect improvements in exertional dyspnea following acute bronchodilation in COPD. Our hypothesis was that the 3-minute constant rate shuttle walking protocol would be able to adequately put forth improvements in exertional dyspnea following acute bronchodilation in this population. Methods: Using a placebo controlled, double-blind cross-over design, 39 patients with moderate to severe COPD performed a 3-min constant rate shuttle walking test during which they were asked to walk on a flat corridor at a speed that was externally imposed by an audio signal. During the test, dyspnea was graded using the 10-point modified Borg scale. The test was performed twice, following the administration of saline placebo or of 500 mu g nebulized ipratropium bromide. Results: Improvements of respiratory pattern (respiratory rate and tidal volume) and statistically and clinically significant reductions in Borg dyspnea scores (Delta dyspnea score = 1.0 +/- 0.2, p %26lt; 0.01) were seen during the 3-min shuttle walking protocol with ipratropium bromide compared to placebo. Conclusion: This 3-minute shuttle walking protocol adequately detected dyspnea and breathing pattern improvements following acute bronchodilation in COPD.

• 出版日期2012-8