New-Generation Drug-Eluting Stent Experience in the Percutaneous Treatment of Unprotected Left Main Coronary Artery Disease: The NEST Registry

作者：Bernelli Chiara^*; Chieffo Alaide; Buchanan Gill Louise; Montorfano Matteo; Carlino Mauro; Latib Azeem; Figini Filippo; Takagi Kensuke; Naganuma Toru; Maccagni Davide; Colombo Antonio

来源：Journal of Invasive Cardiology, 2013, 25(6): 269-275.

• left main
• percutaneous coronary intervention
• new-generation drug-eluting stents

Objectives. To explore the 2-year clinical outcomes in patients with unprotected left main coronary artery (ULMCA) disease treated with overall new drug-eluting stent (DES) options. Background. Recent available data have shown the feasibility and the safety of new DESs, mainly evaluating the everolimus-eluting stents in the setting of ULMCA disease. Methods. Patients with ULMCA disease undergoing percutaneous coronary intervention (PCI) with everolimus-, zotarolimus-, and biolimus A9-eluting stents were prospectively evaluated. The study objective was the composite of major adverse cardiac events (MACEs), consisting of all-cause mortality, myocardial infarction (MI), and target vessel revascularization (TVR) at 2-year clinical follow-up. Results. A total of 154 patients were analyzed. The mean EuroSCORE and SYNTAX scores were 4.7 +/- 2.6 and 27.5 +/- 8.3, respectively. Distal location was present in 126 patients (81.8%) and 96 lesions (76.3%) were true Medina bifurcations. The 2-stent technique was used in 73 cases (57.9%). Everolimus-, zotarolimus-, and biolimus A9-eluting stents were implanted in 68 patients (44.2%), 46 patients (29.9%), and 40 patients (25.9%), respectively. At a median clinical follow-up of 551.5 days (interquartile range, 360.8-1045.5 days), MACEs occurred in 29 patients (18.8%). Ten patients (6.5%) died, and 2 deaths (1.3%) were adjudicated as cardiac. No patient had myocardial infarction or definite stent thrombosis (ST). One probable and 1 possible ST were adjudicated. TVR was required in 19 patients (12.3%) and target lesion revascularization was required in only 7 patients (4.5%). Conclusions. In our experience, despite the presence of complex distal left main lesions, new DESs in ULMCA disease appear to be promising in terms of safety and efficacy at 2-year clinical follow-up.

• 出版日期2013-6