An injectable drug-loaded hydrogel using a "clickable" amphiphilic triblock copolymer as a precursor

作者：Gao, Lilong; Zha, Guangyu; Wang, Ying; Luo, Qiaojie; Zhu, Weipu^*; Shen, Zhiquan; Li, Xiaodong

来源：Polymer Chemistry, 2015, 6(48): 8240-8243.

DOI：10.1039/c5py01383f

• CROSS-LINKING
• DELIVERY
• CHEMISTRY
• RELEASE
• MICELLES
• GELATION
• PROGRESS

We developed a facile strategy to prepare an injectable drug-loaded hydrogel with chemical crosslinkages. A PCL-POEGM-PCL amphiphilic triblock copolymer was synthesized in "one pot" by a combination of polycondensation and ring-opening polymerization, which can disperse hydrophobic drugs in aqueous solution and be crosslinked by POEGMS under physiological conditions.

• 出版日期2015
• 单位浙江大学