Divergent pathways of beta,gamma-unsaturated alpha-diazocarbonyl compounds catalyzed by dirhodium and Lewis acids catalysts separately or in combination

作者：Xu Xin Fang^*; Doyle Michael P

来源：Chinese Chemical Letters, 2015, 26(2): 227-232.

DOI：10.1016/j.cclet.2014.12.014

• Divergent synthesis
• beta,gamma-Unsaturated alpha-diazocarbonyl compounds
• Metal carbene (carbenoid)
• Dirhodium
• Lewis acid catalyst

beta,gamma-Unsaturated alpha-diazocarbonyl compounds possess two reactive sites for electrophilic addition - one at the diazo carbon and the other at the vinylogous gamma-position. Controlled by catalyst, divergent transformations are achieved starting from the same starting materials, either by Lewis acid-catalyzed addition or by dirhodium-catalyzed metal carbene reactions. In select cases two catalysts working in combination or in sequence provide a relay for cascade transformations. In this review, we summarize advances in catalyst-dependent divergent transformations of beta,gamma-unsaturated alpha-diazocarbonyl compounds and highlight the potential of this exciting research area and the many challenges that remain.

• 出版日期2015-2
• 单位苏州大学