Development of Semi-Solid Cosmetic Formulations Containing Coenzyme Q10-Loaded Nanocapsules

作者：Terroso Thatiana; Kulkamp Irene C; Jornada Denise S; Pohlmann Adriana R; Guterres Silvia S^*

来源：Latin American Journal of Pharmacy, 2009, 28(6): 819-826.

• Coenzyme Q10
• Nanocapsules
• Rheological characterization
• Semi-solid formulations

Nanocapsule suspensions containing coenzyme Q10 were prepared by interfacial deposition. The nanocapsules showed characteristics compatible with dermal application: slightly acid pH, drug content close to 100%, particle size between 213 and 248 nm with low polydispersity and negative zeta potential. Three cosmetic formulations for skin application were developed, one with the free-coenzyme Q10, a second with a suspension of coenzyme Q10-loaded nanocapsules and a third containing dried coenzyme Q10-loaded nanocapsules. The dried nanocapsules were obtained by spray-drying of the suspension. No significant differences in the diameters of the particles after their incorporation in the semi-solid formulations were observed in comparison with those of nanocapsules in the aqueous suspension. The rheological characterization showed that the formulations containing coenzyme Q10-loaded nanocapsules had a pseudoplastic flow, while the formulation containing free-coenzyme Q10 had a yield-pseudoplastic flow. The semi-solid formulations containing coenzyme Q10-loaded nanocapsules suspension or powder of nanocapsules of coenzyme Q10 redispersed in water are promising cosmetic formulations for topical application.

• 出版日期2009-12