Drug-eluting stent thrombosis in the treatment of chronic total coronary occlusions: Incidence, presentation and related factors. Data from the CIBELES trial

作者：Arroyo Ucar Eduardo; Moreno Raul; Garcia Eulogio; Teles Rui; Rumoroso Jose Ramon; Carvalho Henrique Cyrne; Javier Goicolea Francisco; Moreu Jose; Mauri Josefa; Sabate Manel; Mainar Vicente; Patricio Lino; Valdes Mariano; Fernandez Vazquez Felipe; Sanchez Recalde Angel; Galeote Guillermo; Jimenez Valero Santiago; Almeida Manuel; Lopez de Sa Esteban; Calvo Luis; Plaza Ignacio; Lopez Sendon Jose Luis; Martin Jose Luis R

来源：Revista Portuguesa de Cardiologia, 2015, 34(3): 193-199.

DOI：10.1016/j.repc.2014.08.026

• Stent
• Thrombosis
• Everolimus
• Sirolimus
• Chronic total coronary occlusion

Introduction and Objectives: The aim of this study was to analyze the incidence of drug-eluting stent thrombosis (sirolimus or everolimus) in patients with chronic total coronary occlusions (CTO) and to determine its clinical implications and related factors.
Methods: Data from the 12-month follow-up of the 207 patients included in the CIBELES trial with CTO were analyzed.
Results: Stent thrombosis occurred in three patients, two definite and one probable (overall thrombosis rate: 1.4%). However, there were no cases of death or Q-wave myocardial infarction. In univariate analysis, patients with a higher incidence of stent thrombosis were those in whom the target vessel was the left anterior descending, who had single-vessel disease, were assigned to treatment with sirolimus-eluting stents, and those with smaller minimum luminal diameter immediately after the procedure. In multivariate analysis, the only independent predictor of stent thrombosis was minimal luminal diameter immediately after the procedure.
Conclusions: The rate of drug-eluting stent thrombosis in patients with CTO is relatively low (1.4%). The only independent predictor of stent thrombosis in this context was minimal luminal diameter after the procedure and the clinical presentation was in all cases relatively benign.

• 出版日期2015-3