Amino Acid-Derived Metabolites from the Ascidian Aplidium sp.

作者：Won Tae Hyung; Kim Chang Kwon; Lee So Hyoung; Rho Boon Jo; Lee Sang Kook; Oh Dong Chan; Oh Ki Bong^*; Shin Jongheon

来源：Marine Drugs, 2015, 13(6): 3836-3848.

DOI：10.3390/md13063836

• dipeptides
• apliamides
• Aplidium sp
• Marfey's analysis
• bioactivities

Four new iodobenzene-containing dipeptides (1-4), a related bromotryptophan-containing dipeptide (5), and an iodophenethylamine (6) were isolated from the ascidian Aplidium sp. collected off the coast of Chuja-do, Korea. The structures of these novel compounds, designated as apliamides A-E (1-5) and apliamine A (6) were determined via combined spectroscopic analyses. The absolute configuration of the amino acid residue in 1 was determined by advanced Marfey's analysis. Several of these compounds exhibited moderate cytotoxicity and significant inhibition against Na+/K+-ATPase (4).

• 出版日期2015-6