科研之友
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摘要
Objective: To establish the value of thallium-201 single-photon emission computed tomography (Tl-201-SPECT) as a predictor of early progression in low-grade astrocytomas (LGAs). %26lt;br%26gt;Methods: We studied 57 consecutive patients who underwent 201 Tl-SPECT before stereotactic biopsy (n = 33) or surgical resection (n = 24). The value of radiologic and histopathological variables (Tl-201 index and MIB-1 index) in predicting progression free survival (PFS) was examined in each group of patients. %26lt;br%26gt;Results: During a median follow up of 55 months (range, 11-101), progression of the primary lesion was identified in 46 patients (80.7%). Based on Cox%26apos;s proportional hazards model, the increased thallium uptake was associated with a short PFS in both biopsy and resection groups, whereas the MIB-1 index was significant only in the resection group. Considering the cut-off value, Tl-201 index %26gt; 1.7 was statistically significant for reduced PFS in the biopsy group; however, MIB-1 index was not directly related to the PFS at any level. For the surgical resection group, both a Tl-201 index %26gt; 1.9 and a MIB-1 index %26gt; 6% were associated with short PFS. %26lt;br%26gt;Conclusion: Tl-201 SPECT may play a role in prediction of early tumor progression not only in resected LGAs, but also in biopsy-proven LGAs. Therefore, we suggest that patients with LGAs established from biopsy should be considered as high-risk groups for early progression if the tumor shows a high Tl-201 uptake, even if the tumor demonstrates low proliferative activity on histopathologic examination.
- 出版日期2012-4
