科研之友
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摘要
Studies have reported the associations between the two single nucleotide polymorphisms (SNPs), -842G>C (rs2233678) and -667C>T (rs2233679), in the PIN1 promoter region and the risk of cancers. However, no studies have reported the association between the PIN1 polymorphisms and risk of colorectal carcinoma. In this study, we investigated the association between the two SNPs -842G>C and -667C>T in PIN1 promoter with risk of colorectal carcinoma (CRC) and clinicopathological parameter of CRC. The results indicated the frequencies of -842G>C and -667C>T genotypes and alleles were not significantly different between the colorectal cancer patients and controls. Interestingly, -667C>T SNP genotypes showed a significant association with clinical stage (P = 0.022). Compared to the -667CC genotype, the -667CT genotype was lower in the advance stage (rate in the advance stage, -667CC: 34/51, -667CT: 27/64). The -842G>C genotype was marginally associated with lymph node status (P = 0.099). In conclusion, our findings suggested that the polymorphic variants of -842G>C and -667C>T in PIN1 promoter were not associated with the risk of CRC but associated with the clinicopathological CRC.
