A simple and straightforward method for determination of oxime group configuration in ethanone oximes by differential NOE experiments

作者：Shashkov Alexander S; Amelichev Stanislav A; Zavarzin Igor V; Rakitin Oleg A^*

来源：Tetrahedron Letters, 2011, 52(43): 5684-5687.

DOI：10.1016/j.tetlet.2011.08.117

• Differential NOE experiment
• Configuration
• Ethanone oximes
• NMR spectroscopy

Differential NOE experiments in DMSO-d(6) with pre-saturation of the =N-OH protons of the oxime are described for the simple and straightforward determination of the configuration of ethanone oximes. A characteristic relative NOE of about 1% has been observed for the methyl group of E-isomers, while the Z-isomers gave an undetectable response together with an NOE interaction to the alpha- or beta-hydrogens on the other substituent attached to oxime carbon atom.

• 出版日期2011-10-26