Association of monocyte chemoattractant protein-1 with adipocyte number, insulin resistance and liver function markers

作者：Bose Tanushree^*; Alvarenga Juan Carlos Lopez; Tejero M Elizabeth; Voruganti V Saroja; Proffitt J Michael; Freeland Graves Jeanne H; Cole Shelley A; Comuzzie Anthony G

来源：Journal of Medical Primatology, 2009, 38(6): 418-424.

DOI：10.1111/j.1600-0684.2009.00379.x

• adipocyte number
• adipocyte volume
• AST and ALT
• insulin resistance
• liver function marker
• MCP-1
• NAFLD

Background
Monocyte chemoattractant protein-1 (MCP-1) is an inflammatory chemokine known to induce adipocyte dedifferentiation and insulin resistance. Inflammation, insulin resistance, and obesity have been implicated in the pathogenesis of non-alcoholic fatty liver disease (NAFLD).
Methods
Fasting plasma from 43 baboons were assayed for MCP-1, insulin, glucose, alanine aminotransferase (ALT), and aspartate aminotransferase (AST). Adipocyte number and volume were measured via biopsies of omental adipose tissue. The homeostatic model assessment method (HOMA) was used to estimate systemic insulin resistance.
Results
Sex and age adjusted correlations were significant for MCP-1 with adipocyte number (r = -0.42; P = 0.01), adipocyte volume (r = 0.38; P = 0.02), HOMA (r = 0.45; P = 0.004), ALT (r = 0.46; P = 0.03) and AST (r = 0.45; P = 0.03).
Conclusions
These results suggest that MCP-1 is related with adipocyte dedifferentiation and systemic insulin resistance, thereby potentially contributing to the development of NAFLD.

• 出版日期2009-12