Association between T lymphocyte sub-sets apoptosis and peripheral blood mononuclear cells oxidative stress in systemic lupus erythematosus

作者：Shah Dilip^*; Aggarwal Ashish; Bhatnagar Archana; Kiran Ravi; Wanchu Ajay

来源：Free Radical Research, 2011, 45(5): 559-567.

DOI：10.3109/10715762.2011.555765

• Reactive oxygen species
• redox system
• T lymphocyte sub-sets
• apoptosis
• systemic lupus erythematosus

Increased oxidative stress and lymphocyte apoptosis are a hallmark of the autoimmune disease systemic lupus erythematosus (SLE). However, the association between oxidative stress and T lymphocytes apoptosis has still to be elucidated in SLE. In order to appraise the interaction between oxidative stress and T lymphocyte apoptosis with the severity of disease, oxidative stress profile and T lymphocytes apoptosis were studied. Increased levels of ROS, MDA and CD4<SU++</SU lymphocyte apoptosis were positively associated with disease activity while decreased levels of GSH and percentage expression of CD4<SU++</SU lymphocyte were negatively associated with disease activity. The decrease in intracellular levels of GSH was negatively associated with T lymphocyte, CD4<SU++</SU lymphocyte, CD8<SU++</SU lymphocyte apoptosis and intracellular caspase-3 expression. The present study suggests that increased T lymphocyte sub-sets apoptosis may be mediated by decreased intracellular glutathione concentration and severity of disease might be enhanced together by over-production of ROS in SLE.

• 出版日期2011-5