Biodegradable inflatable balloons for tissue separation

作者：Basu Arijit; Haim Zada Moran; Domb Abraham J

来源：Biomaterials, 2016, 105: 109-116.

DOI：10.1016/j.biomaterials.2016.08.008

• Bio-balloons
• Poly-L-lactide-co-epsilon-caprolactone
• Biodegradable implants
• Radiation therapy
• Prostate cancer
• Rotator cuff tears

Confining radiation to a specific region (during radiation therapy) minimizes damage to surrounding tissues. Biodegradable inflatable balloons (bio-balloons) were developed. The device protects the normal tissues by increasing the gap between radiation source and critical structures. The radiation fades away while passing through the inflated balloon preventing the surrounding tissues from harmful radiation. These bio-balloons have also found clinical use to treat massive rotator cuff tear. This review summarizes the chemistry, engineering, and clinical development of these biomedical devices. These balloons are made of biodegradable polymers folded into the edge of a trocar and inserted between the tissues to be separated, and inflated by normal saline in the site of the application. The inserted balloon protects the tissues from radiation or mechanical stress. They remain inflated on site for two months and are finally eliminated within 12 months.

• 出版日期2016-10