A new fused tetracyclic heterocyclic antioxidant from Serratia sp PAMC 25557

作者：Bhattarai Hari Datta; Paudel Babita; Chan Kim Il; Oh Hyuncheol; Yim Joung Han^*

来源：Phytochemistry Letters, 2013, 6(4): 536-538.

DOI：10.1016/j.phytol.2013.07.006

• Antioxidant
• DPPH free radical
• Serratia

A new fused tetracyclic heterocyclic compound, (4bR,10bR)-4b-hydroxy-10b,12-dihydrodibenzo[c,h][2,6]naphthyridine-5,11(4bH, 6H)-dione (1), and a known compound, butyl 2-[(benzoyloxy)-methyl] benzoate, spatozoate 2, were isolated from the broth culture of Serratia sp. PAMC 25557. The structure of 1 was determined by analyzing spectroscopic data. Compound 1 did not exhibit antimicrobial activity against Escherichia coli, Staphylococcus aureus, or Candida albicans. In addition, up to 100 mu g/ml compound 1 did not show any toxicity against Artemia salina larvae. However, compound 1 showed DPPH free radical scavenging activity (IC50 = 16.7 +/- 0.34 mu g/ml). This was the first report of spatozoate isolation from bacterial sources.

• 出版日期2013-11
• 单位中国极地研究中心