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摘要
A number of studies have confirmed that circulating tumor cells (CTCs) are closely related with metastatic breast cancer (MBC) prognosis. However, whether CTCs can act as an independent prognostic indicator in MBC remains unclear. Therefore, a meta-analysis of published literatures was carried out to assess the specific role of CTCs in MBC prognosis. Relevant articles were searched online between May 1995 to May 2015 through different databases, and data were extracted to assess the information on the correlation of CTCs with overall survival (OS) and progression-free survival (PFS) in MBC, together with hazard ratios (HRs) and 95% confidence intervals (CIs). Data were pooled from different studies as an effective measure. The identification of five CTCs was significantly and positively associated with short survival time in all MBC patients. OS was observed with HR=2.71 (95% CI: 2.41, 3.05) and PFS was observed with HR=1.88 (95% CI: 1.74, 2.03). Moreover, this correlation was not associated with blood sampling time (OS: HR=2.50, 95% CI [1.73, 3.61]; PFS: HR=2.33, 95% CI [1.80, 3.01]) and treatment methods (OS: HR=1.98, 95% CI [1.53, 2.56]; PFS: HR=1.66, 95% CI [1.36, 2.02]). This present study confirms that the number of CTCs is positively associated with MBC prognosis. CTCs detection can be used as a significant index to guide treatment strategies and evaluate MBC prognosis. Further clinical studies are warranted to establish clinical criteria for the use of CTCs in breast cancer prognosis.
- 出版日期2016
- 单位重庆医科大学
