A copper- and amine-free Sonogashira reaction employing chlorophosphine as new and efficient ligand

作者：Mai, Wen Peng^*; Yuan, Jin Wei; Li, Zhi Cheng; Sun, Gang Chun

来源：Chinese Chemical Letters, 2012, 23(2): 185-188.

DOI：10.1016/j.cclet.2011.11.007

• Palladium
• Copper-free
• Coupling
• Sonogashira reaction
• Chlorophosphine

An efficient palladium-catalyzed copper- and amine-free Sonogashira coupling reaction of aryl bromides and chlorides was studied using a sterically hindered monooxychlorophosphine as new ligand. The use of 2 mol% Pd(OAc)(2) in the presence of K2CO3 allows the coupling reaction to proceed at mild condition with good to excellent yields.

• 出版日期2012-2
• 单位河南工业大学