An Encapsulated Juice Powder Concentrate Improves Markers of Pulmonary Function and Cardiovascular Risk Factors in Heavy Smokers

作者：Bamonti Fabrizia^*; Pellegatta Marco; Novembrino Cristina; Vigna Luisella; De Giuseppe Rachele; de Liso Federica; Gregori Dario; Della Noce Cinzia; Patrini Lorenzo; Schiraldi Gianfranco; Bonara Paola; Calvelli Laura; Maiavacca Rita; Cighetti Giuliana

来源：Journal of the American College of Nutrition, 2013, 32(1): 18-25.

DOI：10.1080/07315724.2013.767652

• tobacco
• homocysteine
• cysteine
• folate
• nutraceutical

Objective: Cigarette smoking is associated with reduced pulmonary function and increased risk factors for cardiovascular disease. This randomized placebo-controlled double-blind study evaluated the effects of two different combinations of mixed fruit and vegetable juice powder concentrate (Juice Plus+, NSA, Collierville, TN) on heavy smokers. %26lt;br%26gt;Methods: At baseline (T-0) and after 3 months%26apos; supplementation (T-1), pulmonary function parameters and cardiovascular risk factors-that is, plasma total homocysteine (tHcy) with related B vitamins and cysteine (tCys) concentrations-were assessed in 75 apparently healthy smokers (aged 49.2 +/- 10.6 years, %26gt;20 cigarettes/d, duration %26gt;= 10 years) randomized into 3 groups: placebo (P), fruit/vegetable (FV) and fruit/vegetable/berry (FVB). %26lt;br%26gt;Results: T-0: most smokers showed abnormalities in tHcy and tCys concentrations. T-1: respiratory function was unchanged in P and slightly, but not significantly, improved in FV, whereas FVB showed a significant improvement in forced expiratory flow at 25% (FEF25; p %26lt; 0.0001 vs P and FV) and significant improvement in CO diffusion lung/alveolar volume (DLCO/VA). FV and FVB (50%) showed significant reduction in tHcy and tCys compared to T-0 (p %26lt; 0.0001) and P (p %26lt; 0.0001). %26lt;br%26gt;Conclusions: At T-1, both supplemented groups, but to a greater extent the FVB group, showed improvements in some pulmonary parameters, cardiovascular risk factors, and folate status. The beneficial effects of Juice Plus+ supplementation could potentially help smokers, even if smoking cessation is advisable.

• 出版日期2013