Waning vaccine immunity in teenagers primed with whole cell and acellular pertussis vaccine: recent epidemiology

作者：Sheridan Sarah L; Frith Katie; Snelling Thomas L; Grimwood Keith; McIntyre Peter B; Lambert Stephen B^*

来源：Expert Review of Vaccines, 2014, 13(9): 1081-1106.

DOI：10.1586/14760584.2014.944167

• acellular pertussis vaccine
• pertussis immunobiology
• teenagers
• vaccine effectiveness
• vaccine efficacy
• waning protection
• whole-cell pertussis vaccine

The recent epidemics of pertussis (whooping cough) in parts of the USA and Australia have led to the largest numbers of annual cases reported in over half a century. These epidemics demonstrated a new pattern, with particularly high rates of disease among pre-adolescents and early adolescents. These high rates of pertussis coincided with the first cohorts vaccinated with purely acellular pertussis vaccine, which replaced whole-cell pertussis (wP) vaccine in the later 1990s in the USA and Australia. Studies undertaken during these epidemics provide new evidence of more rapid waning of acellular pertussis-containing vaccines and longer-term protection from effective wP-containing vaccines. There is evidence that receiving wP as at least the first dose of pertussis-containing vaccine provides greater and more long-lived protection, irrespective of the nature of subsequent doses. This evidence will be reviewed together with the immunobiology associated with both vaccines, and the implications for pertussis control discussed.

• 出版日期2014-9